The aim of this study was to investigate the effects of a combination of ranolazine with\ndifferent selective inhibitors of the Na+/Ca2+-exchanger (NCX) in an established experimental model\nof atrial fibrillation (AF). Eighteen hearts of New Zealand white rabbits were retrogradely perfused.\nAtrial catheters were used to record monophasic action potentials (aPRR). Hearts were paced at\nthree different cycle lengths. Thereby, atrial action potential durations (aAPD90), atrial effective\nrefractory periods (aERP) and atrial post-repolarization refractoriness were obtained. Isoproterenol\nand acetylcholine were employed to increase the occurrence of AF. Thereafter, the hearts were\nassigned to two groups (n = 9 each group) and additionally perfused with a combination\n.................................
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